Kodi machubu osonkhanitsira magazi a EDTA ndi chiyani ndipo amagwiritsidwa ntchito bwanji?

Mu mayeso azachipatala ndi matenda ndi chithandizo chamankhwala,Machubu osonkhanitsira magazi a EDTA, monga zinthu zofunika kwambiri zosonkhanitsira magazi, zimathandiza kwambiri pakutsimikizira kuti zitsanzozo ndi zolondola komanso kuti mayesowo ndi olondola. M'nkhaniyi, tifufuza bwino "woteteza wosaonekayo" uyu m'magawo azachipatala kuchokera ku mbali za tanthauzo, kugawa mitundu, mfundo yoletsa magazi kuundana, cholinga choyesera ndi muyezo wogwiritsira ntchito.

Kodi ndi chiyaniChubu chosonkhanitsira magazi cha EDTA?

Chubu chosonkhanitsira magazi cha EDTA ndi mtundu wa chubu chosonkhanitsira magazi chopanda mpweya chokhala ndi Ethylene Diamine Tetraacetic Acid kapena mchere wake, chomwe chimagwiritsidwa ntchito makamaka posonkhanitsira zitsanzo za magazi ndi mankhwala oletsa magazi kuundana. EDTA imatha kuletsa kuuma kwa magazi mwa kuyika ma calcium ayoni m'magazi, kuti magazi azikhalabe m'madzi kwa nthawi yayitali, ndikupereka zitsanzo zokhazikika zoyeserera magazi ndi ma molecular biology. Imapereka zitsanzo zokhazikika za magazi, ma molecular biology ndi mayeso ena.

Monga gawo lofunika lazinthu zogwiritsidwa ntchito zachipatalaMachubu osonkhanitsira magazi a EDTA ayenera kutsatira muyezo wa dziko lonse wa “Zidebe zosonkhanitsira magazi m'mitsempha zogwiritsidwa ntchito kamodzi” (monga GB/T 19489-2008) kuti zitsimikizire kuti magaziwo ndi osabereka, osayambitsa matenda a pyrogenic komanso osayambitsa matenda a cytotoxicity.

Mitundu yosiyanasiyana ya machubu osonkhanitsira magazi a EDTA

Malinga ndi miyezo yapadziko lonse lapansi (monga malangizo a CLSI H3-A6), machubu osonkhanitsira magazi a EDTA nthawi zambiri amakhala oviikidwa mu utoto wofiirira (EDTA-K2/K3) kapena buluu (sodium citrate yosakanizidwa ndi EDTA) kuti asiyanitse kugwiritsa ntchito:

Dziwani: Mitundu ina ikhoza kukhala ndi ma code amitundu ina, onani malangizo musanagwiritse ntchito.

Njira yoletsa magazi kuundana m'machubu osonkhanitsira magazi a EDTA

EDTA kudzera mu gulu lake la molekyulu ya carboxyl (-COOH) ndi ma calcium ions m'magazi (Ca²⁺) zimagwirizanitsidwa kuti zipange chelate yokhazikika, motero zimaletsa kuyambika kwa plasminogen, ndikuletsa njira yolumikizirana ya fibrinogen kukhala fibrin. Kuletsa kugayika kwa magazi kumeneku kuli ndi makhalidwe awa:

1. Kuyamba mwachangu kugwira ntchito: mankhwala oletsa magazi kuundana amatha kutha mkati mwa mphindi 1-2 magazi atatengedwa;

2. kukhazikika kwakukulu: zitsanzo zitha kusungidwa kwa maola opitilira 48 (mufiriji zitha kukulitsidwa mpaka maola 72);

3. Kugwiritsa ntchito mosiyanasiyana: koyenera mayeso ambiri a magazi, koma osati mayeso a magazi oundana kapena ntchito ya ma platelet (machubu a sodium citrate amafunika).

Zinthu zoyezera magazi za EDTA mu chubu chosonkhanitsira magazi

1. Kusanthula magazi nthawi zonse: kuchuluka kwa maselo oyera m'magazi, magawo a maselo ofiira m'magazi, kuchuluka kwa hemoglobin, ndi zina zotero;

2. kuzindikira ndi kufananiza magulu a magazi: Gulu la magazi la ABO, kuzindikira Rh factor;

3. Kuzindikira ma molekyulu: kuyezetsa majini, kudziwa kuchuluka kwa mavairasi (monga HIV, HBV);

4. hemoglobin yokonzedwa ndi glycated (HbA1c): kuyang'anira shuga m'magazi kwa nthawi yayitali kwa matenda a shuga;

5. Kuyezetsa magazi a tizilombo toyambitsa matenda: Kuzindikira Plasmodium, microfilariae.

Kugwiritsa ntchito malamulo ndi njira zodzitetezera

1. Njira yosonkhanitsira:

Mukatsuka pakhungu ndi mankhwala ophera tizilombo toyambitsa matenda, gwirani ntchito motsatira muyezo wa kusonkhanitsa magazi m'mitsempha;

Mukangomaliza kusonkhanitsa magazi, tembenuzani chubu chosonkhanitsira magazi nthawi 5-8 kuti muwonetsetse kuti mankhwala oletsa magazi asakanikirana bwino ndi magazi;

Pewani kugwedezeka mwamphamvu (kuti mupewe kutuluka magazi m'magazi).

2. Kusunga ndi mayendedwe:

Sungani kutentha kwa chipinda (15-25°C), pewani kutentha kapena kuzizira;

Ikani molunjika pamene mukuyendetsa kuti chivundikiro cha chubu chisamasuke.

3. zochitika zotsutsana ndi kugwiritsa ntchito:

Machubu a sodium citrate amafunika kuti magazi azitsekeka m'mitsempha ya m'magazi (PT, APTT, ndi zina zotero);

Kuyesa kwa ntchito ya ma platelet kumafuna chubu cha sodium citrate.

Momwe mungasankhire khalidwe lapamwambaChubu chosonkhanitsira magazi cha EDTA?

1. Ziyeneretso ndi satifiketi: sankhani zinthu zomwe zapambana satifiketi ya ISO13485 ndi CE. 2;

2. Chitetezo cha zinthu: thupi la chubu liyenera kukhala lowonekera bwino komanso lopanda zotsalira za pulasitiki;

3. Mlingo wolondola: kuchuluka kwa mankhwala oletsa magazi oundana omwe awonjezeredwa kuyenera kugwirizana ndi muyezo wa dziko lonse (monga kuchuluka kwa EDTA-K2 kwa 1.8±0.15mg/mL);

4. Mbiri ya mtundu: Makampani odziwika bwino pankhani ya zinthu zachipatala amapatsidwa udindo waukulu kuti atsimikizire kuti zinthu zonse zili bwino.

Mapeto

Monga membala wofunikira wachipangizo chosonkhanitsira magazi, Machubu osonkhanitsira magazi a EDTA amakhudza mwachindunji kulondola kwa zotsatira za mayeso malinga ndi mphamvu zawo zoletsa magazi kuundana. Mwa kuyika njira yokhazikika yogwiritsira ntchito machubu osonkhanitsira magazi okhala ndi mitundu yosiyanasiyana ndikusakaniza ndi njira zosonkhanitsira zolimba, zingapereke maziko odalirika odziwira matenda. M'tsogolomu, ndi chitukuko cha mankhwala olondola, machubu osonkhanitsira magazi a EDTA adzakhala ndi gawo lofunika kwambiri pakusanthula magazi, kusanthula majini ndi madera ena, ndikupitiriza kuteteza thanzi la anthu.