njira zambiri zogwiritsira ntchito ma microspheres a embolic

Ma Microspheres a Embolic ndi ma microspheres a hydrogel opanikizika okhala ndi mawonekedwe ofanana, pamwamba posalala, ndi kukula kolinganizidwa, omwe amapangidwa chifukwa cha kusintha kwa mankhwala pazinthu za polyvinyl alcohol (PVA). Ma Microspheres a Embolic ali ndi macromer ochokera ku polyvinyl alcohol (PVA), ndipo ndi okonda madzi, osasinthika, ndipo amapezeka m'mitundu yosiyanasiyana. Yankho losungira ndi 0.9% sodium chloride solution. Madzi a microsphere yopangidwa ndi polymer ndi 91% ~ 94%. Ma Microspheres amatha kupirira kupsinjika kwa 30%.

Ma Microspheres a Embolic apangidwa kuti agwiritsidwe ntchito pochotsa ma arteriovenous malformations (AVMs) ndi zotupa za hypervascular, kuphatikizapo uterine fibroids. Mwa kuletsa magazi kupita kudera lomwe likufunidwa, chotupacho kapena malformation sichikhala ndi michere yambiri ndipo kukula kwake kumachepa.

M'nkhaniyi, tikuwonetsani njira zatsatanetsatane za momwe mungagwiritsire ntchito Embolic Microspheres.

Kukonzekera katundu

Ndikofunikira kukonzekera sirinji imodzi ya 20ml, sirinji ziwiri za 10ml, sirinji zitatu za 1ml kapena 2ml, lumo la opaleshoni, chikho choyeretsera, mankhwala a chemotherapy, ma microspheres a embolic, contrast media, ndi madzi oti mubayire.

Gawo 1: Konzani mankhwala a chemotherapy

Gwiritsani ntchito lumo la opaleshoni kutsegula botolo la mankhwala a chemotherapeutic ndikutsanulira mankhwala a chemotherapeutic mu kapu yopanda poizoni.
Mtundu ndi mlingo wa mankhwala a chemotherapy zimadalira zosowa zachipatala.

Gwiritsani ntchito madzi obayira kuti musungunule mankhwala a chemotherapy, ndipo kuchuluka kovomerezeka ndi kopitilira 20mg/ml.

APambuyo poti mankhwala a chemotherapeutic asungunuka kwathunthu, yankho la mankhwala a chemotherapeutic limachotsedwa ndi sirinji ya 10ml.

Gawo 2: Kutulutsa ma microspheres a embolic omwe ali ndi mankhwala osokoneza bongo

Ma microspheres opangidwa ndi emboli adagwedezeka kwathunthu, ndikuyikidwa mu singano ya syringe kuti azitha kupanikizika bwino m'botolo,ndipo chotsani yankho ndi ma microspheres kuchokera mu botolo la cillin ndi sirinji ya 20ml.

Lolani syringe iyime kwa mphindi 2-3, ndipo ma microspheres atatha kukhazikika, supernatant imakankhidwira kunja kwa yankho.

Gawo 3: Ikani mankhwala a Chemotherapeutic mu Embolic Microspheres

Gwiritsani ntchito njira zitatu zolumikizira stopcock kuti mulumikize syringe ndi embolic microsphere ndi syringe ndi mankhwala a chemotherapy, samalani ndi kulumikizana kwake mwamphamvu komanso komwe kukuyenda.
Kanikizani syringe ya mankhwala a chemotherapy ndi dzanja limodzi, ndipo kokani syringe yokhala ndi ma microspheres a embolic ndi dzanja lina. Pomaliza, mankhwala a chemotherapy ndi ma microsphere amasakanizidwa mu syringe ya 20ml, gwedezani syringe bwino, ndikusiya kwa mphindi 30, gwedezani mphindi 5 zilizonse panthawi yonse ya msambo.

Gawo 4: Onjezani zowonera zosiyana

Pambuyo poti ma microspheres adzazidwa ndi mankhwala a chemotherapeutic kwa mphindi 30, kuchuluka kwa yankho kunawerengedwa.
Onjezani kuchuluka kwa contrast agent 1-1.2 kuposa voliyumu kudzera mu stopcock ya njira zitatu, gwedezani bwino ndikusiya kuti ziime kwa mphindi 5.

Gawo 5: Ma Microspheres amagwiritsidwa ntchito mu njira ya TACE

Kudzera mu stopcock ya njira zitatu, ikani pafupifupi 1ml ya microspheres mu syringe ya 1ml.

Ma microspheres analowetsedwa mu microcatheter pogwiritsa ntchito pulsed injection.

Malangizo otsogolera:

Onetsetsani kuti ntchito ya aseptic ikuyenda bwino.
Tsimikizani kuti mankhwala a chemotherapy asungunuka kwathunthu musanalowetse mankhwalawo.
Kuchuluka kwa mankhwala a chemotherapy kudzakhudza momwe mankhwalawo amakhudzira kuchuluka kwa mankhwalawa, kuchuluka kwake kukakhala kwakukulu, kuchuluka kwa madzi omwe amatengedwa kumawonjezeka mofulumira, ndipo kuchuluka kwa mankhwala omwe amalimbikitsidwa sikochepera 20mg/ml.
Madzi oyera okha oti jakisoni kapena jakisoni wa 5% wa shuga ayenera kugwiritsidwa ntchito kusungunula mankhwala a chemotherapy.
Mlingo wa kusungunuka kwa doxorubicin m'madzi osagwiritsidwa ntchito pobayira unali wothamanga pang'ono kuposa 5% ya shuga woperekedwa.
Kubayidwa kwa shuga wa 5% kumasungunula pirarubicin mofulumira pang'ono kuposa madzi oyera obayidwa.
Kugwiritsa ntchito ioformol 350 ngati chosinthira chosiyanitsa zinthu kunali kothandiza kwambiri pakuyimitsidwa kwa ma microspheres.
Mukabayidwa mu chotupa kudzera mu microcatheter, jakisoni wa pulse umagwiritsidwa ntchito, zomwe zimathandiza kwambiri kuyimitsidwa kwa microsphere.